Risky, early, controversial. Puberty in medical discourses

Early Puberty Due to Ovarian Granulosa Tumor

A 7½-year-old girl is reported showing pre­cocious puberty and large abdominal mass for a year. The right ovarial cyst removed by surgery revealed histopathologically a granu­losa cell tumor. After removal of the tumor the estrogens were still increased and the signs of puberty showed no regression. This seems to be due to the hormonal activity of the metas­tases. Liver metastasis was present a...

Early Puberty in a Two-year-old Boy

Precocious Puberty in a 2-year-old boy  A 2-year-old boy with precocious isosexual matura- (3) Lion is reported.  The pubertal values of serum LH, FSH and Testoste- (4) on and lack of any other pathologic finding were in favour of diagnosis of idiopathic sexual precocity.  The L.R.F. response test was of the adult pattern. The serum LH, FSH and Testosterone decreased following (5) treatment ...

Early puberty: a cautionary tale.

The controversial early history of cyclosporin.

The biological effects of cyclosporin, namely immunosuppression and absence of cytotoxicity, were discovered-in the course of a general screening program in which many scientists at Sandoz were involved. Contrary to some statements in the literature both Dr J. Borel and Dr H. Stähelin markedly contributed to the discovery and characterisation of the biological profile of the drug. In its subseq...

Neuroenhancement – A Controversial Topic in Contemporary Medical Ethics

Neuroenhancement will become an important topic of medical ethics in future years and decades, due to the increasing insights of neuroscience into the functions of the brain and the growing possibilities of meaningful interventions. Consequently, several crucial topics need to be discussed in order to address this emerging issue, and these topics correspond to the following sections of this art...